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Breast cancer bone secondaries

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Skip to Content. Use the menu to see other pages. If metastatic breast cancer develops, it may or may not cause symptoms. Sometimes these symptoms may lead a doctor to perform tests to find metastatic breast cancer or learn if an earlier breast cancer has metastasized. Testing to look for metastatic disease may also be performed if a patient is diagnosed with locally advanced breast cancer but doesn't have any symptoms. You can find information on diagnosing breast cancer in the Diagnosis section of the earlier-stage Breast Cancer guide.

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Journal of Clinical and Experimental Investigations

Secondary (metastatic) breast cancer in the bone | Breast Cancer Now

Metastatic breast cancer commonly spreads to the bones. Learn the signs and symptoms of bone metastasis — plus how to treat it. When breast cancer spreads beyond the breast, one of the most common places it goes is the bones it may also spread to the lungs, liver, or brain. Wilmot Cancer Institute at the University of Rochester. While breast cancer can metastasize to any bone in the body, it most commonly spreads to the spine, pelvis, ribs, and long bones of the arms and legs humerus and femur. Typically, bone pain is the first sign that cancer has spread to the bone. In some cases, however, bone metastases cause little or no symptoms, and it takes a routine scan or fracture from a minor fall or injury to uncover the bone cancer.

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Therapeutic targets for bone metastases in breast cancer

A moderate amount of a peptide-enhanced, biological cancer drug goes a long way in treating breast cancers that metastasize to the bone. A study by scientists at Rice University and Baylor College of Medicine demonstrated the effective treatment of such cancers in rodent models, bringing hope for new therapies to treat bone metastases. They discovered through extensive testing that engineering "bone-homing" peptides and attaching them to a common breast cancer drug, the antibody trastuzumab, effectively targets and attacks bone tumors. The researchers reported their surprise that injecting more of the drug compound doesn't make it better. The drug contains an engineered peptide that finds and binds to bone, but worked best when a moderate amount was delivered.

Breast Cancer Research volume 13 , Article number: Cite this article. Metrics details. Breast cancer is prone to metastasize to bone. Once metastatic cells are in the bone marrow, they do not, on their own, destroy bone. Instead, they alter the functions of bone-resorbing osteoclasts and bone-forming cells osteoblasts , resulting in skeletal complications that cause pathological fractures and pain.